Prediction of tissue-prediction partition coefficient using Poulin&Theil method — Kpcoeff_PT • KpCoeff

Prediction of tissue-prediction partition coefficient using Poulin&Theil method

Usage

Kpcoeff_PT(logP, pKa, fup, BP = 1, type = 1, dattype = 0)

Arguments

logP: Partition coefficient
pKa: Acid dissociation
fup: Plasma unbound fraction
BP: Blood-plasma ratio
type: Neutral/acid/base
dattype: Human physiology dataset

Value

A list of tissue partition coefficient in each organ

Examples

Kpcoeff_PT(2.7, 6, 0.9, 1, 1, 0)
#> $Kpad
#> [1] 28.76542
#> 
#> $Kpbo
#> [1] 11.78282
#> 
#> $Kpbr
#> [1] 10.89885
#> 
#> $Kpgu
#> [1] 8.624007
#> 
#> $Kphe
#> [1] 2.82252
#> 
#> $Kpki
#> [1] 4.252819
#> 
#> $Kpli
#> [1] 6.876856
#> 
#> $Kplu
#> [1] 1.148512
#> 
#> $Kpmu
#> [1] 4.306328
#> 
#> $Kpsp
#> [1] 4.330372
#> 
#> $Kpsk
#> [1] 5.198043
#>