KpCoeff is an R package for prediction of tissue-plasma partition coefficients (Kp) using published method with published/unified dataset. KpCoeff is free and open-source software.
Installation
Install the current development version
library(devtools)
remotes::install_github("sueinchoi/KpCoeff")Interaction
We welcome questions about anything KpCoeff: installation, dataset, how it works, reference, understanding better how KpCoeff works. We also welcome suggestions for how to make KpCoeff more useful to you and to the PBPK community.
Some examples
A simple simulation
Predict the tissue-plasma partition coefficient using P&T method with reference dataset
KpCoeff(1.9, 6.4, 0.01, 1, 3, "P&T", 0)Predict the tissue-plasma partition coefficient using R&R method with unified dataset
KpCoeff(1.9, 6.4, 0.01, 1, 3, "R&R", 1)The result can be direcly incorporated to the simulation model from mrgsolve package
Example of using KpCoeff result with mrgsolve package will be soon updated